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sympathomimetic amine anorectic. Indicated as a short-term adjunct (a few weeks) in a

regimen of weight reduction based on exercise, behavioral modification.

Caloric restriction in the management of exogenous obesity for patients. With an initial body mass

index ≥ 30 kg/m2, or ≥ 27 kg/m2 in the presence of other risk factors (for example,controlled hypertension,

diabetes, hyperlipidemia).

(1) The limited usefulness of agents of this class, including ADIPEX-P®, should be measured

against possible risk factors inherent in their use.

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DOSAGE AND ADMINISTRATION

  • Firstly, dosage should be individualized to obtain an adequate response.
  • secondly, rare cases of serious regurgitant cardiac valvular disease have been reported.
  • Tolerance to the anorectic effect usually develops within a few weeks. If this occurs, phentermine should be discontinued. The recommended dose should not be exceeded.
  • Further, Phentermine may impair the ability of the patient to engage in potentially hazardous activities. For example, operating machinery or driving a motor vehicle.
  • Risk of abuse and dependence. The least amount feasible should be prescribed or dispensed at one time in order to minimize the possibility of overdosage.
  • Moreover, concomitant alcohol use may result in an adverse drug reaction.
  • Use caution in patients with even mild hypertension (risk of increase in blood pressure).
  • A reduction in the dose of insulin or oral hypoglycemic medication may be required in some patients.

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CONTRAINDICATIONS

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In short, the history of cardiovascular disease (such as coronary artery disease, stroke,

  • arrhythmias, congestive heart failure, uncontrolled hypertension) during or within 14 days following the administration of monoamine
  • Oxidase inhibitors
  • Hyperthyroidism
  • Glaucoma
  • Agitated states
  • History of drug abuse
  • Pregnancy
  • Nursing
  • Known hypersensitivity or idiosyncrasy to the sympathomimetic amines.

WARNINGS AND PRECAUTIONS

Coadministration with Other Drug Products for Weight Loss.

Most importantly, suprenza is indicated only as short-term (a few weeks) monotherapy for the management

of exogenous obesity. The safety and efficacy of combination therapy with Suprenza and any other drug

products for weight loss. Including prescribed drugs, over-the-counter preparations, and herbal

products, or serotonergic agents. For example, as selective serotonin reuptake inhibitors

(e.g., fluoxetine, sertraline, fluvoxamine, paroxetine), have not been established.

Therefore, coadministration of Suprenza and these drug products is not recommended.

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Primary Pulmonary Hypertension

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In addition.To clarify, Primary Pulmonary Hypertension (PPH) – a rare, frequently fatal disease of the lungs. – has been

reported to occur in patients. Receiving a combination of phentermine with fenfluramine

or dexfenfluramine.

However, the possibility of an association between PPH and the use of Suprenza alone cannot be ruled out. There

have been rare cases of PPH in patients who reportedly have taken phentermine alone.

Firstly the initial symptom of PPH is usually dyspnea. On the other hand, other initial symptoms may include angina pectoris,

syncope or lower extremity edema.

Doctors should advise patients to report immediately any deterioration in exercise tolerance.

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Doctors should discontinue treatment  in patients who develop new, unexplained symptoms of

dyspnea, angina pectoris, syncope or lower extremity edema, and patients should be evaluated

for the possible presence of pulmonary hypertension.

OVERDOSAGE

That is to say, doctors should prescribe or dispense the least amount feasible at one time. So that they can minimize

the possibility of overdosage.

Acute Overdosage

For example, manifestations of acute overdosage include restlessness, tremor, hyperreflexia, rapid

respiration, confusion, assaultiveness, hallucinations, and panic states.

Consequently, fatigue and depression usually follow the central stimulation.

Cardiovascular effects include tachycardia, arrhythmia, hypertension or hypotension, and circulatory collapse. Gastrointestinal symptoms include nausea, vomiting, diarrhea and abdominal cramps.

However, overdosage of pharmacologically similar compounds has resulted in fatal poisoning

usually terminates in convulsions and coma.

In conclusion, the management of acute phentermine hydrochloride intoxication is largely symptomatic and

includes lavage and sedation with a barbiturate. Meanwhile, experience with hemodialysis or peritoneal

dialysis is inadequate to permit recommendations in this regard. Intravenous phentolamine

Therefore, pharmacologists suggest for possible acute, severe (Regitine®, CIBA) on pharmacologic grounds

hypertension if this complicates overdosage. Wiki

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